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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733900
Species: Mus musculus
RGD Object: Gene
Symbol: Rad50
Name: RAD50 double strand break repair protein
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rad50multiple interactionsEXP 6480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD50 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA]PMID:20230807
Rad50increases expressionISORAD50 (Homo sapiens)6480464CTDNicotine results in increased expression of RAD50 mRNAPMID:16949557
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