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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733306
Species: Homo sapiens
RGD Object: Gene
Symbol: SMO
Name: smoothened, frizzled class receptor
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SMOincreases expressionEXP 6480464CTDCisplatin results in increased expression of SMO mRNAPMID:27392435
SMOmultiple interactionsEXP 6480464CTDCisplatin promotes the reaction [jinfukang results in increased expression of SMO mRNA]; jinfukang promotes the reaction [Cisplatin results in increased expression of SMO mRNA]PMID:27392435
SMOincreases expressionISOSmo (Rattus norvegicus)6480464CTDCisplatin results in increased expression of SMO mRNAPMID:31612257
SMOmultiple interactionsISOSmo (Rattus norvegicus)6480464CTD[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]PMID:31612257
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