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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733054
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGER1
Name: prostaglandin E receptor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGER1affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of PTGER1 promoterPMID:27901495
PTGER1decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of PTGER1 5' UTRPMID:27901495
PTGER1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of PTGER1 3' UTR; Benzo(a)pyrene results in increased methylation of PTGER1 exonPMID:27901495
PTGER1increases response to substanceISOPtger1 (Mus musculus)6480464CTDPTGER1 results in increased susceptibility to Benzo(a)pyrenePMID:21739481
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