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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732783
Species: Homo sapiens
RGD Object: Gene
Symbol: KL
Name: klotho
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of KL mRNAPMID:19152381
KLincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of KL exon; Benzo(a)pyrene results in increased methylation of KL promoterPMID:27901495
KLmultiple interactionsEXP 6480464CTDchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of KL mRNA]PMID:19152381
KLincreases expressionISOKl (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of KL mRNAPMID:27195522
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