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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:36062
Term: 3,4-dihydroxybenzoic acid
Definition: A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Chemical ID: MESH:C009091
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATincreases activityISOCat (Rattus norvegicus)6480464CTDprotocatechuic acid results in increased activity of CAT proteinPMID:29842870
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTDprotocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of CAT mRNA]; protocatechuic acid inhibits the reaction [furan results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]PMID:32392679 PMID:32758512 PMID:36593721
CATmultiple interactionsISOCat (Mus musculus)6480464CTDprotocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]PMID:33497687 PMID:36807594
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