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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATmultiple interactionsEXP 6480464CTD[Zinc Sulfate co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein; Zinc Sulfate inhibits the reaction [Disulfiram results in decreased expression of CAT mRNA]PMID:24368744 PMID:32712770
CATdecreases activityISOCat (Rattus norvegicus)6480464CTDZinc Sulfate results in decreased activity of CAT proteinPMID:20553223
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTD[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; [Zinc Sulfate results in increased abundance of Zinc] which results in decreased activity of CAT protein; Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of CAT protein]; Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]; Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of CAT protein]PMID:20553223 PMID:22422511 PMID:32864810
CATmultiple interactionsISOCat (Mus musculus)6480464CTD[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT proteinPMID:20118189
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