Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	732520
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	BMAL1
Name:	basic helix-loop-helix ARNT like 1

Acc ID:	CHEBI:16240
Term:	hydrogen peroxide
Definition:	An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID:	MESH:D006861

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
BMAL1	affects expression	EXP		6480464	CTD	Hydrogen Peroxide affects the expression of BMAL1 mRNA; Hydrogen Peroxide affects the expression of BMAL1 protein	PMID:29061316 PMID:30316844
BMAL1	multiple interactions	EXP		6480464	CTD	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of BMAL1 mRNA]; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of BMAL1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP5F1A mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1L mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of OPA1 mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of PINK1 mRNA]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRFS1 mRNA]]; Polyphenols affects the reaction [Hydrogen Peroxide affects the expression of BMAL1 mRNA]; Polyphenols affects the reaction [Hydrogen Peroxide affects the expression of BMAL1 protein]	PMID:29061316 PMID:30316844
BMAL1	multiple interactions	ISO	Bmal1 (Mus musculus)	6480464	CTD	BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]; BMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]	PMID:30316844

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