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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731948
Species: Mus musculus
RGD Object: Gene
Symbol: Slc6a2
Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a2multiple interactionsEXP 6480464CTD[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]PMID:16725121
Slc6a2decreases activityISOSLC6A2 (Homo sapiens)6480464CTDNorepinephrine results in decreased activity of SLC6A2 proteinPMID:11082428
Slc6a2decreases expressionISOSLC6A2 (Homo sapiens)6480464CTDNorepinephrine results in decreased expression of SLC6A2 proteinPMID:11082428
Slc6a2decreases uptakeISOSLC6A2 (Homo sapiens)6480464CTDSLC6A2 mutant form results in decreased uptake of NorepinephrinePMID:11458707
Slc6a2increases uptakeISOSLC6A2 (Homo sapiens)6480464CTDSLC6A2 protein results in increased uptake of NorepinephrinePMID:30776375
Slc6a2multiple interactionsISOSlc6a2 (Rattus norvegicus)6480464CTD[Cullen corylifolium extract results in decreased activity of SLC6A2 protein] which results in decreased uptake of Norepinephrine; Norepinephrine affects the localization of and affects the metabolism of SLC6A2 proteinPMID:16338971 PMID:17555897
Slc6a2multiple interactionsISOSLC6A2 (Homo sapiens)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A2 protein results in increased uptake of Norepinephrine]; Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein]; SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]PMID:11082428 PMID:17234900 PMID:30776375
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