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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731885
Species: Mus musculus
RGD Object: Gene
Symbol: Alpl
Name: alkaline phosphatase, liver/bone/kidney
Acc ID: CHEBI:5801
Term: hydroxychloroquine
Definition: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Chemical ID: MESH:D006886
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alplaffects expressionISOALPL (Homo sapiens)6480464CTDHydroxychloroquine affects the expression of ALPL mRNAPMID:28975700
Alplmultiple interactionsISOALPL (Homo sapiens)6480464CTDHydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]PMID:28975700
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