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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731551
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
Acc ID: CHEBI:4659
Term: disulfiram
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Chemical ID: MESH:D004221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLMincreases expressionEXP 6480464CTDDisulfiram results in increased expression of GCLM mRNAPMID:20566472
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