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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731513
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDAtorvastatin results in increased phosphorylation of EIF2S1 proteinPMID:20876807
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 mutant form inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]PMID:20876807
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