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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731513
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1multiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [Acrolein results in increased phosphorylation of EIF2S1 protein]PMID:34813903
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of EIF2S1 proteinPMID:17914584 PMID:22898769
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of EIF2S1 mRNA; Resveratrol inhibits the reaction [Ethanol results in increased expression of EIF2S1 protein modified form]PMID:23557933 PMID:24224909
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