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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCincreases activityEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of MYC proteinPMID:27589886
MYCincreases expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of MYC mRNA; Dichlorodiphenyl Dichloroethylene results in increased expression of MYC proteinPMID:25386960 PMID:38568856
MYCmultiple interactionsEXP 6480464CTDCTNNB1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of MYC protein]; GLI1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of MYC protein]PMID:25386960
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