GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP3 | decreases expression | EXP | | 6480464 | CTD | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CASP3 mRNA | PMID:20957409 | CASP3 | increases activity | EXP | | 6480464 | CTD | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP3 protein | PMID:17169355 PMID:17979179 | CASP3 | increases expression | EXP | | 6480464 | CTD | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CASP3 protein | PMID:18778698 | CASP3 | multiple interactions | EXP | | 6480464 | CTD | [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]] | PMID:15966574 PMID:16844947 PMID:19887557 | | ||||||||||||||||||||||
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