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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:5615
Term: halothane
Definition: A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Chemical ID: MESH:D006221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2increases expressionISONos2 (Rattus norvegicus)6480464CTDHalothane results in increased expression of NOS2 proteinPMID:16965849
NOS2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDHalothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein]PMID:11506125 PMID:16965849
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