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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730881
Species: Homo sapiens
RGD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:6651
Term: malathion
Definition: A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.
Chemical ID: MESH:D008294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HRASincreases expressionEXP 6480464CTDMalathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS proteinPMID:18204794 PMID:19787260
HRASmultiple interactionsEXP 6480464CTD[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNAPMID:18204794
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