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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:82701
Term: idelalisib
Definition: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.
Chemical ID: MESH:C552946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8multiple interactionsEXP 6480464CTD[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; AKT activator SC79 inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]PMID:31445927
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