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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:23086
Term: chalcones
Definition: A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
Chemical ID: MESH:D047188
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8increases expressionEXP 6480464CTDChalcones analog results in increased expression of CASP8 mRNAPMID:32856275
CASP8multiple interactionsEXP 6480464CTDBCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP8 proteinPMID:30576621
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