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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Asic1
Name: acid sensing ion channel subunit 1
Acc ID: CHEBI:15746
Term: spermine
Definition: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
Chemical ID: MESH:D013096
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Asic1multiple interactionsEXP 6480464CTDSpider Venoms inhibits the reaction [Spermine results in increased activity of ASIC1 protein]PMID:21307247
Asic1decreases response to substanceISOAsic1 (Mus musculus)6480464CTDASIC1 gene mutant form results in decreased susceptibility to SperminePMID:21307247
Asic1increases activityISOAsic1 (Mus musculus)6480464CTDSpermine results in increased activity of ASIC1 proteinPMID:21307247
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