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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708432
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trib3
Name: tribbles pseudokinase 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trib3decreases expressionEXP 6480464CTDCisplatin results in decreased expression of TRIB3 mRNAPMID:22023808
Trib3affects expressionISOTRIB3 (Homo sapiens)6480464CTDCisplatin affects the expression of TRIB3 mRNAPMID:23300844
Trib3affects response to substanceISOTRIB3 (Homo sapiens)6480464CTDTRIB3 protein affects the susceptibility to CisplatinPMID:16217747
Trib3decreases expressionISOTrib3 (Mus musculus)6480464CTDCisplatin results in decreased expression of TRIB3 mRNAPMID:21151649 PMID:25270620
Trib3increases expressionISOTRIB3 (Homo sapiens)6480464CTDCisplatin results in increased expression of TRIB3 mRNAPMID:19561079 PMID:27594783
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