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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:45735
Term: troleandomycin
Definition: A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.
Chemical ID: MESH:D014217
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9decreases activityISOCYP3A5 (Homo sapiens)6480464CTDTroleandomycin results in decreased activity of CYP3A5 proteinPMID:15557344
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTDTroleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]PMID:15731592
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