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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdm3a
Name: lysine demethylase 3A
Acc ID: CHEBI:110423
Term: clodronic acid
Definition: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Chemical ID: MESH:D004002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdm3adecreases expressionISOKDM3A (Homo sapiens)6480464CTDClodronic Acid results in decreased expression of KDM3A mRNAPMID:25596134
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