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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70514
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk5
Name: cyclin-dependent kinase 5
Acc ID: CHEBI:6067
Term: isotretinoin
Definition: A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.
Chemical ID: MESH:D015474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk5decreases expressionISOCDK5 (Homo sapiens)6480464CTDIsotretinoin results in decreased expression of CDK5 mRNAPMID:20436886
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