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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:49305
Term: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol
Definition: An oxysterol that has formula C27H46O2.
Chemical ID: MESH:C002415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDcholesterol alpha-oxide results in increased phosphorylation of MAPK1 proteinPMID:20466046
Mapk1multiple interactionsEXP 6480464CTDRTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein]PMID:20466046
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