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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14decreases expressionEXP 6480464CTDLosartan results in decreased expression of MAPK14 proteinPMID:28091615
Mapk14multiple interactionsEXP 6480464CTD[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]PMID:34590760
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