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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14decreases expressionISOMAPK14 (Homo sapiens)6480464CTDMethotrexate results in decreased expression of MAPK14 mRNAPMID:19100307
Mapk14increases phosphorylationISOMAPK14 (Homo sapiens)6480464CTDMethotrexate results in increased phosphorylation of MAPK14 proteinPMID:19100307
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [Methotrexate results in increased phosphorylation of MAPK14 protein]PMID:19100307
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