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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70492
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nat2
Name: N-acetyltransferase 2
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat2affects metabolic processingISONAT2 (Homo sapiens)6480464CTDNAT2 protein affects the metabolism of BenzenePMID:15226677
Nat2affects response to substanceISONAT2 (Homo sapiens)6480464CTDNAT2 gene polymorphism affects the susceptibility to BenzenePMID:15226677
Nat2increases response to substanceISONAT2 (Homo sapiens)6480464CTDNAT2 gene polymorphism results in increased susceptibility to BenzenePMID:15226677
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