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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69649
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr2
Name: inositol 1,4,5-trisphosphate receptor, type 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr2affects expressionISOItpr2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ITPR2 mRNAPMID:21570461
Itpr2decreases expressionISOITPR2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ITPR2 mRNAPMID:20106945 PMID:21632981
Itpr2decreases expressionISOItpr2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ITPR2 mRNAPMID:26290441
Itpr2increases expressionISOItpr2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ITPR2 mRNAPMID:17035482 PMID:20819909
Itpr2multiple interactionsISOItpr2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ITPR2 gene]PMID:20819909
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