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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69649
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr2
Name: inositol 1,4,5-trisphosphate receptor, type 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr2decreases expressionISOItpr2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of ITPR2 mRNAPMID:33754040 PMID:34319233
Itpr2multiple interactionsISOITPR2 (Homo sapiens)6480464CTD[Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of ITPR2 genePMID:33872906
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