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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69363
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nupr1
Name: nuclear protein 1, transcriptional regulator
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nupr1decreases expressionISONUPR1 (Homo sapiens)6480464CTDCadmium results in decreased expression of NUPR1 mRNAPMID:24376830
Nupr1multiple interactionsISONUPR1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NUPR1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NUPR1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NUPR1 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NUPR1 mRNA]; NUPR1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATG7 mRNA]; NUPR1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATP6V0D1 mRNA]; NUPR1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CTSB mRNA]; NUPR1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LAMP1 mRNA]; NUPR1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased metabolism of MAP1LC3B protein]PMID:31319114 PMID:31738976 PMID:35301059
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