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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:15846
Term: NAD(+)
Definition: The oxidised form of nicotinamide adenine dinucleotide found in all living cells. In metabolism, NAD(+) is involved in redox reactions, carrying electrons from one reaction to another.
Chemical ID: MESH:D009243
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1amultiple interactionsEXP 6480464CTDNAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]PMID:22561310
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