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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:72312
Term: pasireotide
Definition: A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease.
Chemical ID: MESH:C517782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1multiple interactionsEXP 6480464CTDpasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]PMID:23137853
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTDNOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]PMID:23137853
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