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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1increases expressionEXP 6480464CTDColforsin results in increased expression of CYP11A1 proteinPMID:22948218
Cyp11a1multiple interactionsEXP 6480464CTD[Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]PMID:22948218 PMID:25253736
Cyp11a1affects expressionISOCYP11A1 (Homo sapiens)6480464CTDColforsin affects the expression of CYP11A1 mRNAPMID:20726872
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDColforsin results in increased expression of CYP11A1 mRNAPMID:14691014 PMID:16935330 PMID:17080404 PMID:22446829 PMID:25765474 PMID:25871633 PMID:28235592
Cyp11a1multiple interactionsISOCYP11A1 (Homo sapiens)6480464CTD[Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of CYP11A1 mRNA]PMID:16935330 PMID:17080404 PMID:18936084 PMID:20726872 PMID:31557376
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNAPMID:26783879
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