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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNAPMID:11026553 PMID:16141434 PMID:16254025 PMID:18637154 PMID:19276399 PMID:32031418 PMID:32109520
Cyp11a1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP11A1 mRNAPMID:33387578
Cyp11a1multiple interactionsEXP 6480464CTDGonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 protein]PMID:15930178 PMID:19276399
Cyp11a1decreases expressionISOCYP11A1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNAPMID:25697571
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 proteinPMID:15223135 PMID:22889882 PMID:24793433
Cyp11a1increases expressionISOCyp11a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP11A1 mRNAPMID:16962184 PMID:28213091
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP11A1 mRNA; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 protein]PMID:15223135 PMID:17942748
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