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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1affects expressionEXP 6480464CTDEstradiol affects the expression of CYP11A1 mRNAPMID:36931579
Cyp11a1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of CYP11A1 mRNA; Estradiol results in decreased expression of CYP11A1 proteinPMID:16311018 PMID:18191889 PMID:20144698 PMID:22771390 PMID:22777679 PMID:23209616
Cyp11a1multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [Estradiol affects the expression of CYP11A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP11A1 mRNA]PMID:23209616 PMID:36931579
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDEstradiol results in decreased expression of CYP11A1 mRNAPMID:14648872
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDEstradiol results in increased expression of CYP11A1 mRNAPMID:12858341
Cyp11a1increases expressionISOCyp11a1 (Mus musculus)6480464CTDEstradiol results in increased expression of CYP11A1 mRNAPMID:30196065
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