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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:45951
Term: trifluoperazine
Definition: A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Chemical ID: MESH:D014268
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases expressionEXP 6480464CTDTrifluoperazine results in decreased expression of ACHE proteinPMID:15232633
Achemultiple interactionsEXP 6480464CTDenergostim inhibits the reaction [Trifluoperazine results in decreased expression of ACHE protein]PMID:15232633
Acheincreases activityISOAche (Mus musculus)6480464CTDTrifluoperazine results in increased activity of ACHE proteinPMID:29614332
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