Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	69305
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Nr2f2
Name:	nuclear receptor subfamily 2, group F, member 2

Acc ID:	CHEBI:34687
Term:	dibutyl phthalate
Definition:	A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID:	MESH:D003993

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Nr2f2	decreases expression	EXP		6480464	CTD	Dibutyl Phthalate results in decreased expression of NR2F2 mRNA	PMID:21266533
Nr2f2	increases expression	EXP		6480464	CTD	Dibutyl Phthalate results in increased expression of NR2F2 protein	PMID:22615892
Nr2f2	multiple interactions	EXP		6480464	CTD	[[Dibutyl Phthalate co-treated with Dexamethasone] results in increased expression of NR2F2 protein] which results in decreased abundance of Testosterone; [Dibutyl Phthalate co-treated with Dexamethasone] results in increased expression of NR2F2 protein; [Dibutyl Phthalate results in increased expression of NR2F2 protein] which results in decreased abundance of Testosterone	PMID:22615892
Nr2f2	decreases expression	ISO	Nr2f2 (Mus musculus)	6480464	CTD	Dibutyl Phthalate results in decreased expression of NR2F2 mRNA	PMID:21266533

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