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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh2
Name: cadherin 2
Acc ID: CHEBI:85993
Term: palbociclib
Definition: A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.
Chemical ID: MESH:C500026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh2increases expressionISOCDH2 (Homo sapiens)6480464CTDpalbociclib results in increased expression of CDH2 proteinPMID:22869556
Cdh2multiple interactionsISOCDH2 (Homo sapiens)6480464CTD2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein]PMID:22869556
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