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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69273
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Socs2
Name: suppressor of cytokine signaling 2
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Socs2decreases expressionISOSOCS2 (Homo sapiens)6480464CTDProgesterone results in decreased expression of SOCS2 mRNAPMID:21768398
Socs2multiple interactionsISOSOCS2 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of SOCS2 mRNA; [Progesterone co-treated with TGFB1 protein] results in decreased expression of SOCS2 mRNAPMID:20660070 PMID:21768398
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