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GENE - TERM ANNOTATION REPORT

RGD ID: 69259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Axin2
Name: axin 2
Acc ID: DOID:9007071
Term: Hereditary Neoplastic Syndromes
Definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Definition Source(s): MESH:D009386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Axin2 ISOAXIN2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Neoplastic Syndromes, HereditaryPMID:11017067 PMID:12101426 PMID:15042511 PMID:15841489 PMID:16199547 PMID:16820935 PMID:16941501 PMID:17373666 PMID:17576681 PMID:19065536 PMID:21069480 PMID:21294210 PMID:21416598 PMID:21472303 PMID:21476993 PMID:21520333 PMID:21541676 PMID:21626677 PMID:23838596 PMID:24033266 PMID:24581859 PMID:25151137 PMID:25236910 PMID:25260786 PMID:25637381 PMID:25741868 PMID:26467025 PMID:26580448 PMID:26681312 PMID:27009842 PMID:27090353 PMID:27300758 PMID:27491081 PMID:27696107 PMID:28265457 PMID:28492532 PMID:28577310 PMID:28717660 PMID:28944238 PMID:29114927 PMID:29212164 PMID:29341116 PMID:29371908 PMID:29446198 PMID:29625052 PMID:29641532 PMID:30093976 PMID:30262796 PMID:30322717 PMID:30374176 PMID:30555066 PMID:30760879 PMID:30822429 PMID:31285513 PMID:31769227 PMID:32807118 PMID:32984025 PMID:33193653 PMID:33359728 PMID:33558524 PMID:33606809 PMID:33725141 PMID:34817745 PMID:9536098
Axin2 ISOAXIN2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Hereditary neoplastic syndrome | ClinVar Annotator: match by term: Neoplastic Syndromes, HereditaryPMID:11017067 PMID:12101426 PMID:15042511 PMID:15735151 PMID:15841489 PMID:16199547 PMID:16820935 PMID:16941501 PMID:17373666 PMID:17576681 PMID:19065536 PMID:21069480 PMID:21294210 PMID:21416598 PMID:21472303 PMID:21476993 PMID:21520333 PMID:21541676 PMID:21626677 PMID:22581971 PMID:23838596 PMID:24033266 PMID:24581859 PMID:25151137 PMID:25236910 PMID:25260786 PMID:25637381 PMID:25741868 PMID:26467025 PMID:26580448 PMID:26681312 PMID:27009842 PMID:27090353 PMID:27153395 PMID:27300758 PMID:27491081 PMID:27696107 PMID:28265457 PMID:28492532 PMID:28577310 PMID:28717660 PMID:28944238 PMID:29114927 PMID:29212164 PMID:29341116 PMID:29371908 PMID:29446198 PMID:29458332 PMID:29625052 PMID:29641532 PMID:30093976 PMID:30262796 PMID:30322717 PMID:30374176 PMID:30555066 PMID:30760879 PMID:30822429 PMID:31285513 PMID:31721781 PMID:31769227 PMID:31811167 PMID:31819260 PMID:32807118 PMID:32984025 PMID:33193653 PMID:33359728 PMID:33558524 PMID:33606809 PMID:33725141 PMID:34196900 PMID:34817745 PMID:35014770 PMID:35904628 PMID:36071541 PMID:36502525 PMID:36672847 PMID:9536098
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