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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69235
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htra1
Name: HtrA serine peptidase 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htra1affects response to substanceISOHTRA1 (Homo sapiens)6480464CTDHTRA1 protein affects the susceptibility to FluorouracilPMID:15352031
Htra1increases expressionISOHTRA1 (Homo sapiens)6480464CTDFluorouracil results in increased expression of HTRA1 proteinPMID:15352031
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