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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69226
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:84050
Term: trabectedin
Definition: A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.
Chemical ID: MESH:C099150
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases expressionISOGPX4 (Homo sapiens)6480464CTDTrabectedin results in decreased expression of GPX4 mRNA; Trabectedin results in decreased expression of GPX4 proteinPMID:36396105
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