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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9multiple interactionsEXP 6480464CTDGlutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein]PMID:12140745 PMID:18594523
CASP9multiple interactionsISOCasp9 (Mus musculus)6480464CTDGlutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP9 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]PMID:33309544 PMID:36689145
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