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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pawr
Name: pro-apoptotic WT1 regulator
Acc ID: CHEBI:8983
Term: SC-58125
Definition: A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property.
Chemical ID: MESH:C090859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pawrincreases expressionISOPAWR (Homo sapiens)6480464CTD1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole results in increased expression of PAWR mRNAPMID:10833474
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