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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69022
Species: Homo sapiens
RGD Object: Gene
Symbol: FDPS
Name: farnesyl diphosphate synthase
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FDPSaffects bindingEXP 6480464CTDzoledronic acid binds to FDPS proteinPMID:16684881
FDPSdecreases activityEXP 6480464CTDzoledronic acid results in decreased activity of FDPS proteinPMID:11160603 PMID:17208200 PMID:18325729 PMID:19621390 PMID:19699819
FDPSincreases activityEXP 6480464CTDzoledronic acid results in increased activity of FDPS proteinPMID:12846887
FDPSincreases expressionEXP 6480464CTDzoledronic acid results in increased expression of FDPS mRNAPMID:24714768
FDPSmultiple interactionsEXP 6480464CTD[zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphatePMID:19699819
FDPSdecreases activityISOFdps (Rattus norvegicus)6480464CTDzoledronic acid results in decreased activity of FDPS proteinPMID:18325729
FDPSincreases expressionISOFdps (Rattus norvegicus)6480464CTDzoledronic acid results in increased expression of FDPS mRNAPMID:18325729
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