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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:7449
Term: nafenopin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-nafenopin. It is a peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an hypolipidemic agent.
Chemical ID: MESH:D009255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4a1increases expressionEXP 6480464CTDNafenopin results in increased expression of CYP4A1 mRNAPMID:18079279 PMID:19647067
Cyp4a1multiple interactionsEXP 6480464CTDOkadaic Acid inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]; tautomycin inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]PMID:18079279
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