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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68627
Species: Mus musculus
RGD Object: Gene
Symbol: Cldn1
Name: claudin 1
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn1decreases expressionEXP 6480464CTDDextran Sulfate results in decreased expression of CLDN1 proteinPMID:27920472 PMID:37001609 PMID:38648921
Cldn1increases expressionEXP 6480464CTDDextran Sulfate results in increased expression of CLDN1 proteinPMID:36543318
Cldn1multiple interactionsEXP 6480464CTD7-hydroxyl-1-methylindole-3-acetonitrile inhibits the reaction [Dextran Sulfate results in increased expression of CLDN1 protein]; [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Dextran Sulfate] results in decreased expression of CLDN1 protein; [SB 203580 co-treated with Dextran Sulfate] results in decreased expression of CLDN1 protein; biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein]; hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein]PMID:27920472 PMID:36543318 PMID:37001609 PMID:38648921
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