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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68420
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dio3
Name: iodothyronine deiodinase 3
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio3increases activityEXP 6480464CTDFluoxetine results in increased activity of DIO3 proteinPMID:15456934
Dio3increases expressionEXP 6480464CTDFluoxetine results in increased expression of DIO3 mRNAPMID:15456934
Dio3multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased activity of DIO3 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]PMID:15456934
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