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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cox4i1
Name: cytochrome c oxidase subunit 4i1
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cox4i1affects response to substanceISOCOX4I1 (Homo sapiens)6480464CTDCOX4I1 protein affects the susceptibility to temozolomidePMID:20870728
Cox4i1increases expressionISOCOX4I1 (Homo sapiens)6480464CTDtemozolomide results in increased expression of COX4I1 proteinPMID:20870728
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