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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cox4i1
Name: cytochrome c oxidase subunit 4i1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cox4i1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of COX4I1 mRNAPMID:34747641
Cox4i1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of COX4I1 mRNAPMID:33387578
Cox4i1affects expressionISOCox4i1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of COX4I1 mRNA; Tetrachlorodibenzodioxin affects the expression of COX4I1 proteinPMID:21570461 PMID:27105554
Cox4i1increases expressionISOCox4i1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of COX4I1 mRNAPMID:18172213 PMID:20399798
Cox4i1multiple interactionsISOCox4i1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to COX4I1 promoter]PMID:19654925
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